Abstract
In Caenorhabditis elegans, the dauer pheromone, which consists of a number of derivatives of the 3,6-dideoxysugar ascarylose, is the primary cue for entry into the stress-resistant, "nonaging" dauer larval stage. Here, using activity-guided fractionation and NMR-based structure elucidation, a structurally novel, indole-3-carboxyl-modified ascaroside is identified that promotes dauer formation at low nanomolar concentrations but inhibits dauer formation at higher concentrations.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Caenorhabditis elegans / chemistry*
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Caenorhabditis elegans / growth & development
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Caenorhabditis elegans / physiology
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Hexoses / chemistry*
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Hexoses / metabolism*
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Hexoses / pharmacology
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Indoles / chemistry*
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Indoles / metabolism
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Indoles / pharmacology
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Larva / growth & development
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Molecular Structure
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Pheromones / chemistry*
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Pheromones / metabolism*
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Pheromones / pharmacology
Substances
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Hexoses
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Indoles
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Pheromones
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indolecarboxyl-ascaroside C5