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The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes.
Exp Cell Res. 2009 Nov 1;315(18):3112-24. doi: 10.1016/j.yexcr.2009.08.016. Epub 2009 Sep 2.
Exp Cell Res. 2009.
PMID: 19732768
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E.
Goettsch C, et al.
J Clin Invest. 2016 Apr 1;126(4):1323-36. doi: 10.1172/JCI80851. Epub 2016 Mar 7.
J Clin Invest. 2016.
PMID: 26950419
Free PMC article.
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Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.
Li J, Wang Y, Matye DJ, Chavan H, Krishnamurthy P, Li F, Li T.
Li J, et al.
J Biol Chem. 2017 Jan 6;292(1):146-160. doi: 10.1074/jbc.M116.762005. Epub 2016 Nov 23.
J Biol Chem. 2017.
PMID: 27881673
Free PMC article.
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Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A.
Jansen P, et al.
Nat Neurosci. 2007 Nov;10(11):1449-57. doi: 10.1038/nn2000. Epub 2007 Oct 14.
Nat Neurosci. 2007.
PMID: 17934455
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