Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population

S Olschwang; P Laurent-Puig; A Vassal; R J Salmon; G Thomas

doi:10.1007/BF00201836

Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population

Hum Genet. 1991 Feb;86(4):369-70. doi: 10.1007/BF00201836.

Authors

S Olschwang¹, P Laurent-Puig, A Vassal, R J Salmon, G Thomas

Affiliation

¹ Laboratoire de Génétique Moléculaire des Tumeurs, Institut Curie, Paris, France.

PMID: 1999338
DOI: 10.1007/BF00201836

Abstract

We describe a simple method for characterizing a frequent polymorphism (that substitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. We could find no evidence that this polymorphism is associated with a marked predisposition to colorectal cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Colonic Neoplasms / genetics*
Gene Frequency
Genetic Carrier Screening
Humans
Molecular Sequence Data
Oligonucleotide Probes
Polymerase Chain Reaction
Polymorphism, Genetic*
Rectal Neoplasms / genetics*
Reference Values
Tumor Suppressor Protein p53 / genetics*

Substances

Oligonucleotide Probes
Tumor Suppressor Protein p53