Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons

PLoS One. 2009 Dec 22;4(12):e8392. doi: 10.1371/journal.pone.0008392.

Abstract

Nuclear receptors (NRs) comprise a family of ligand-regulated transcription factors that control diverse critical biological processes including various aspects of brain development. Eighteen NR genes exist in the Drosophila genome. To explore their roles in brain development, we knocked down individual NRs through the development of the mushroom bodies (MBs) by targeted RNAi. Besides recapitulating the known MB phenotypes for three NRs, we found that unfulfilled (unf), an ortholog of human photoreceptor specific nuclear receptor (PNR), regulates axonal morphogenesis and neuronal subtype identity. The adult MBs develop through remodeling of gamma neurons plus de-novo elaboration of both alpha'/beta' and alpha/beta neurons. Notably, unf is largely dispensable for the initial elaboration of gamma neurons, but plays an essential role in their re-extension of axons after pruning during early metamorphosis. The subsequently derived MB neuron types also require unf for extension of axons beyond the terminus of the pruned bundle. Tracing single axons revealed misrouting rather than simple truncation. Further, silencing unf in single-cell clones elicited misguidance of axons in otherwise unperturbed MBs. Such axon guidance defects may occur as MB neurons partially lose their subtype identity, as evidenced by suppression of various MB subtype markers in unf knockdown MBs. In sum, unf governs axonal morphogenesis of multiple MB neuron types, possibly through regulating neuronal subtype identity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aging
  • Animals
  • Axons / metabolism*
  • Biomarkers / metabolism
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / cytology*
  • Drosophila melanogaster / metabolism*
  • Gene Knockdown Techniques
  • Gene Silencing
  • MicroRNAs / metabolism
  • Morphogenesis
  • Mushroom Bodies / cytology*
  • Mushroom Bodies / growth & development
  • Mushroom Bodies / metabolism*
  • Phenotype
  • Receptors, Cytoplasmic and Nuclear / metabolism*

Substances

  • Biomarkers
  • Drosophila Proteins
  • Hr51 protein, Drosophila
  • MicroRNAs
  • Receptors, Cytoplasmic and Nuclear