Abstract
To assess dissemination of OXA-23-producing strains of Acinetobacter baumannii, we obtained 20 carbapenem-resistant, OXA-23-producing isolates from different regions. Their clonal relationship was assessed by pulsed-field gel electrophoresis and multilocus sequence typing. We identified 8 sequence types, including 4 novel types. All except 2 strains belonged to 2 main European clonal lineages. The blaOXA-23 gene was either located on the chromosome or on plasmids and associated with 4 genetic structures.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / diet therapy
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Acinetobacter Infections / epidemiology
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / drug effects
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Acinetobacter baumannii / enzymology
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Acinetobacter baumannii / genetics*
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Blotting, Southern
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Cloning, Molecular
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Electrophoresis, Gel, Pulsed-Field
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Gene Transfer, Horizontal / genetics
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Genes, Bacterial / genetics
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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beta-Lactam Resistance / genetics
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beta-Lactamases / genetics*
Substances
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beta-lactamase OXA-23
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beta-Lactamases
Associated data
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GENBANK/EF059914
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GENBANK/EF127491
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GENBANK/GQ861438
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GENBANK/GQ861439