Abstract
Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Catalytic Domain
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Dinoflagellida / metabolism*
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology
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Humans
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Macrolides / chemistry
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Macrolides / isolation & purification
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Macrolides / metabolism*
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Macrolides / pharmacology*
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Marine Toxins / biosynthesis*
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Marine Toxins / chemistry
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Marine Toxins / isolation & purification
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Marine Toxins / pharmacology*
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Okadaic Acid / analogs & derivatives*
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Okadaic Acid / metabolism
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Okadaic Acid / pharmacology*
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Protein Binding
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Protein Phosphatase 1 / antagonists & inhibitors
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Protein Phosphatase 1 / chemistry
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Protein Phosphatase 1 / physiology
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Protein Phosphatase 2 / antagonists & inhibitors
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Protein Phosphatase 2 / chemistry
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Protein Phosphatase 2 / physiology
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Species Specificity
Substances
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Enzyme Inhibitors
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Macrolides
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Marine Toxins
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Okadaic Acid
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Protein Phosphatase 1
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Protein Phosphatase 2