Abstract
The major histocompatibility complex (MHC) class I has a role in the regulation of immune responses and has been implicated recently in neural plasticity and neurogenesis. We therefore sought to investigate in functional MHC class I knockout mice, transporter associated with antigen processing 1 (TAP1) KO, whether there are alterations in adult neurogenesis. We found no significant differences in cell proliferation or neurogenesis in either the dentate gyrus or subventricular zone, in TAP1 KO versus wild-type mice at several different time points. Our results do not support a role for MHC class I in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 2
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ATP-Binding Cassette Transporters / genetics*
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ATP-Binding Cassette Transporters / metabolism*
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Adult Stem Cells / physiology
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Aging
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Animals
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Anxiety / genetics
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Anxiety / metabolism
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Brain / growth & development
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Brain / physiology
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Cell Proliferation
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Dentate Gyrus / growth & development
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Dentate Gyrus / physiology
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Genes, MHC Class I*
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Maze Learning / physiology
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Memory / physiology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Neurogenesis / genetics*
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Neurogenesis / physiology*
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Neurons / physiology
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Space Perception / physiology
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Stem Cell Niche / growth & development
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Stem Cell Niche / physiology
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 2
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ATP-Binding Cassette Transporters
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Tap1 protein, mouse