Evaluation of maxillary alveolar reconstruction using a resorbable collagen sponge with recombinant human bone morphogenetic protein-2 in cleft lip and palate patients

Tissue Eng Part C Methods. 2010 Oct;16(5):1183-9. doi: 10.1089/ten.TEC.2009.0824.

Abstract

Introduction: A resorbable collagen matrix with recombinant human bone morphogenetic protein (rhBMP-2) was compared with traditional iliac crest bone graft for the closure of alveolar defects during secondary dental eruption.

Methods: Sixteen patients with unilateral cleft lip and palate, aged 8 to 12 years, were selected and randomly assigned to group 1 (rhBMP-2) or group 2 (iliac crest bone graft). Computed tomography was performed to assess both groups preoperatively and at months 6 and 12 postoperatively. Bone height and defect volume were calculated through Osirix Dicom Viewer (Pixmeo, Apple Inc.). Overall morbidity was recorded.

Results: Preoperative and follow-up examinations revealed progressive alveolar bone union in all patients. For group 1, final completion of the defect with a 65.0% mean bone height was detected 12 months postoperatively. For group 2, final completion of the defect with an 83.8% mean bone height was detected 6 months postoperatively. Dental eruption routinely occurred in both groups. Clinical complications included significant swelling in three group 1 patients (37.5%) and significant donor-site pain in seven group 2 patients (87.5%).

Conclusions: For this select group of patients with immature skeleton, rhBMP-2 therapy resulted in satisfactory bone healing and reduced morbidity compared with traditional iliac crest bone grafting.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Bone Morphogenetic Protein 2 / administration & dosage*
  • Child
  • Cleft Lip / surgery*
  • Cleft Palate / surgery*
  • Collagen*
  • Humans
  • Recombinant Proteins / administration & dosage
  • Tomography, X-Ray Computed

Substances

  • Bone Morphogenetic Protein 2
  • Recombinant Proteins
  • Collagen