Recent progress in research on ribosome inactivating proteins

Curr Protein Pept Sci. 2010 Feb;11(1):37-53. doi: 10.2174/138920310790274662.

Abstract

The intent of this article is to review recent literature on ribosome inactivating proteins (RIPs) including isolation and characterization of new RIPs, studies on the crystal structures and mechanisms of actions of RIPs, the use of saporin-based neurotoxins to selectively lesion cholinergic neurons in neuroscience research, and the use of RIP-based conjugates and immunotoxins in anticancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunotoxins / chemistry
  • Immunotoxins / pharmacology
  • Neurons / drug effects
  • Protein Conformation
  • Ribosome Inactivating Proteins / chemistry*
  • Ribosome Inactivating Proteins / isolation & purification
  • Ribosome Inactivating Proteins / metabolism*
  • Ribosome Inactivating Proteins, Type 1 / chemistry
  • Ribosome Inactivating Proteins, Type 1 / pharmacology
  • Saporins
  • Structure-Activity Relationship

Substances

  • Immunotoxins
  • Ribosome Inactivating Proteins, Type 1
  • Ribosome Inactivating Proteins
  • Saporins