Functional dendritic polymer architectures as stimuli-responsive nanocarriers

Marcelo Calderón; Mohiuddin A Quadir; Miriam Strumia; Rainer Haag

doi:10.1016/j.biochi.2010.02.017

Functional dendritic polymer architectures as stimuli-responsive nanocarriers

Biochimie. 2010 Sep;92(9):1242-51. doi: 10.1016/j.biochi.2010.02.017. Epub 2010 Mar 6.

Authors

Marcelo Calderón¹, Mohiuddin A Quadir, Miriam Strumia, Rainer Haag

Affiliation

¹ Organic and Macromolecular Chemistry, Department of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.

PMID: 20211678
DOI: 10.1016/j.biochi.2010.02.017

Abstract

Stimuli-responsive polymer architectures are molecular systems which evolve with an external signal. The observed changes are mainly decomposition, isomerization, polymerization, activation, supramolecular aggregation, and structural modifications of these molecules. The external stimuli, which can be combined in order to provoke these molecular changes, are numerous. In this review, we have chosen to present an overview on different mechanisms to impart responsiveness to dendritic polymers, with the particular aim of delivery and release of bioactive molecules.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Dendrimers / chemistry*
Drug Carriers / chemistry*
Hydrogen-Ion Concentration
Nanotechnology / methods
Oxidation-Reduction

Substances

Dendrimers
Drug Carriers