Dysfunctional endothelial progenitor cells in chronic kidney disease

J Am Soc Nephrol. 2010 Jun;21(6):911-9. doi: 10.1681/ASN.2009111119. Epub 2010 Apr 15.

Abstract

Putative endothelial progenitor cells play a role in organ regeneration, and their incompetence may be important in the development of chronic kidney disease. The mechanisms of this incompetence are broad and range from poor mobilization, viability, and engraftment to impaired differentiation into mature endothelial cells. By contrasting the role of endothelial progenitor cells in tissue regeneration with their developing incompetence in chronic kidney disease, we emphasize the importance of designing rational pharmacologic strategies to tackle such incompetence in the broader search for therapies to attenuate chronic disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation / physiology
  • Cell Movement / physiology
  • Chronic Disease
  • Endothelial Cells / cytology
  • Endothelial Cells / physiology*
  • Humans
  • Kidney / cytology
  • Kidney / physiology
  • Kidney Diseases / pathology
  • Kidney Diseases / physiopathology*
  • Regeneration / physiology
  • Signal Transduction / physiology
  • Stem Cells / cytology
  • Stem Cells / physiology*