Impaired sperm aggregation in Adam2 and Adam3 null mice

Cecil Han; Jun Tae Kwon; Inju Park; Boyeon Lee; Sora Jin; Heejin Choi; Chunghee Cho

doi:10.1016/j.fertnstert.2010.03.013

Impaired sperm aggregation in Adam2 and Adam3 null mice

Fertil Steril. 2010 May 15;93(8):2754-6. doi: 10.1016/j.fertnstert.2010.03.013. Epub 2010 Apr 18.

Authors

Cecil Han¹, Jun Tae Kwon, Inju Park, Boyeon Lee, Sora Jin, Heejin Choi, Chunghee Cho

Affiliation

¹ Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, South Korea.

PMID: 20400072
DOI: 10.1016/j.fertnstert.2010.03.013

Abstract

Previous studies have shown that sperm from Adam2 and Adam3 knockout mice have defective migration in the female reproductive tracts and cannot bind to the egg's zona pellucida (ZP), which leads to infertility. Here, we report that Adam2 and Adam3 knockout sperm have severely impaired sperm aggregation and that this defect is not restored over time during in vitro cultivation, suggesting the requirement of ADAM2 and ADAM3 in normal sperm association.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ADAM Proteins / deficiency*
Animals
Cell Aggregation / physiology*
Female
Fertilins
Male
Membrane Glycoproteins / deficiency*
Mice
Mice, Knockout
Spermatozoa / metabolism*
Spermatozoa / physiology
Zona Pellucida / metabolism*

Substances

Membrane Glycoproteins
ADAM Proteins
Adam2 protein, mouse
Adam3 protein, mouse
Fertilins