Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3658-63. doi: 10.1016/j.bmcl.2010.04.100. Epub 2010 Apr 26.

Abstract

Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antitubercular Agents
  • Humans
  • Lipopeptides / isolation & purification
  • Lipopeptides / pharmacology*
  • Lipopeptides / therapeutic use
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium / drug effects*
  • Mycobacterium / growth & development
  • Mycobacterium bovis / drug effects
  • Mycobacterium smegmatis / drug effects
  • Mycobacterium tuberculosis / drug effects
  • Porifera / microbiology
  • Trichoderma / chemistry*

Substances

  • Anti-Bacterial Agents
  • Antitubercular Agents
  • Lipopeptides
  • trichoderin A
  • trichoderin A1
  • trichoderin B