Two new bisindole alkaloids from the seeds of Strychnos nux-vomica

Guang-Ming Yang; Xia Tu; Liang-Jing Liu; Yang Pan

doi:10.1016/j.fitote.2010.06.009

Two new bisindole alkaloids from the seeds of Strychnos nux-vomica

Fitoterapia. 2010 Oct;81(7):932-6. doi: 10.1016/j.fitote.2010.06.009. Epub 2010 Jun 15.

Authors

Guang-Ming Yang¹, Xia Tu, Liang-Jing Liu, Yang Pan

Affiliation

¹ Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210029, China.

PMID: 20558256
DOI: 10.1016/j.fitote.2010.06.009

Abstract

The reinvestigation of Strychnos nux-vomica resulted in the isolation of two colorless monoquaternary bisindole alkaloids from the seeds. The structures of the two new compounds named 4-N-hydroxymethyl strychnidin-17-acetic acid (1) and 10, 11-dimethoxy-4-N-hydroxymethyl strychnidin-17-acetic acid (2), were defined by detailed spectral analyses, especially (1)H NMR, (13)C NMR, DEPT, HSQC, (1)H NMR-(1)H NMR, NOESY, HMBC and TOF-MS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Molecular Structure
Plant Extracts / chemistry*
Plant Extracts / isolation & purification
Seeds
Strychnos / chemistry*

Substances

10,11-dimethoxy-4-N-hydroxymethyl strychnidin-17-acetic acid
4-N-hydroxymethyl strychnidin-17-acetic acid
Indole Alkaloids
Plant Extracts