Abstract
Proline-rich acidic protein 1 mRNA is highly expressed in the uterine luminal epithelium (LE) of day 0.5 mouse uterus, disappears in the preimplantation day 3.5 uterus, and reappears abundantly in the LE after embryo implantation has occurred or upon artificial decidualization. In ovariectomized uterus, Prap1 is down-regulated by P, transiently down-regulated by E(2) treatment for 6 hours, but dramatically induced by E(2) treatment for 3 days.
Published by Elsevier Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biomarkers / analysis
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Biomarkers / metabolism*
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Embryo Implantation / genetics*
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Embryo, Mammalian / metabolism
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Embryonic Development / drug effects
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Embryonic Development / genetics
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Epithelium / drug effects
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Epithelium / metabolism*
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Estradiol / pharmacology
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Female
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Gene Expression Regulation, Developmental / drug effects
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Glycoproteins / genetics
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Glycoproteins / metabolism
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Glycoproteins / physiology
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Organ Specificity / genetics
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Pregnancy
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Pregnancy Proteins / genetics
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Pregnancy Proteins / metabolism
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Pregnancy Proteins / physiology*
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Receptors, Lysophosphatidic Acid / genetics
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Serpins / genetics
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Serpins / metabolism
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Serpins / physiology
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Uterus / drug effects
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Uterus / metabolism*
Substances
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Biomarkers
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Glycoproteins
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Pregnancy Proteins
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Receptors, Lysophosphatidic Acid
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Serpins
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pregnant specific uterus protein, PSUP
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uterine luminal fluid proteins
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Estradiol