Abstract
Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / microbiology*
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Acinetobacter Infections / mortality
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / pathogenicity*
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Animals
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Colistin / pharmacology*
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Disease Models, Animal
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Drug Resistance, Bacterial*
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Female
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Mice
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Mice, Inbred C57BL
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Mutation
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Peritonitis / microbiology
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Peritonitis / mortality
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Sepsis / microbiology
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Sepsis / mortality
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Survival Analysis
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Transcription Factors / genetics
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Virulence
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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PmrB protein, bacteria
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Transcription Factors
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Colistin