This study proposes a health socialization model and applies it to examine direct, relative and mediating roles of interpersonal and media health socialization agents in predicting adolescent self-reported health literacy. We conducted a paper-and-pencil survey among 452 seventh graders in rural and urban school districts. Our regression analysis results show that both interpersonal and media socialization agents are significantly and positively related to adolescent health literacy. Media socialization agents seem to play a strong role in health literacy orientation, not much weaker than those of interpersonal socialization agents. The proposed health socialization model could contribute to the literature on how adolescents acquire health-related information and channels through which they are most receptive.