Mutation Vif-22H, which allows HIV-1 to use the APOBEC3G hypermutation to develop resistance, could appear more quickly in certain non-B variants

J Antimicrob Chemother. 2011 Apr;66(4):941-2. doi: 10.1093/jac/dkr012. Epub 2011 Feb 3.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • APOBEC-3G Deaminase
  • Adaptation, Biological
  • Cytidine Deaminase / genetics
  • Cytidine Deaminase / metabolism*
  • Drug Resistance, Viral
  • Genotype
  • HIV-1 / genetics
  • HIV-1 / immunology*
  • HIV-1 / pathogenicity*
  • Humans
  • Mutation, Missense*
  • Recombination, Genetic
  • Virulence Factors / genetics
  • Virulence Factors / metabolism*
  • vif Gene Products, Human Immunodeficiency Virus / genetics
  • vif Gene Products, Human Immunodeficiency Virus / metabolism*

Substances

  • Virulence Factors
  • vif Gene Products, Human Immunodeficiency Virus
  • vif protein, Human immunodeficiency virus 1
  • APOBEC-3G Deaminase
  • APOBEC3G protein, human
  • Cytidine Deaminase