Emergence of NDM-1-producing Enterobacteriaceae in Belgium

Antimicrob Agents Chemother. 2011 Jun;55(6):3036-8. doi: 10.1128/AAC.00049-11. Epub 2011 Mar 28.

Abstract

Five multidrug-resistant nonclonally related Enterobacteriaceae isolates were recovered in Belgium in 2010 from three patients who had been hospitalized in Pakistan, Montenegro, and Serbia/Kosovo. New Delhi metallo-β-lactamase (NDM-1) was detected in each of the isolates in addition to several extended-spectrum β-lactamases (CTX-M-15, SHV-12), plasmidic cephalosporinases (CMY-16, CMY-58), rRNA methylases (ArmA, RmtB), and Qnr genes (qnrA6, qnrB1, qnrB2). One patient died from uncontrolled sepsis, while the two others recovered. No secondary cases occurred in any of the hospitals.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Belgium
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology*
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • beta-Lactamases / biosynthesis*

Substances

  • beta-Lactamases
  • beta-lactamase NDM-1