Cyclosporin A--a review on fermentative production, downstream processing and pharmacological applications

Shrikant A Survase; Lalit D Kagliwal; Uday S Annapure; Rekha S Singhal

doi:10.1016/j.biotechadv.2011.03.004

Cyclosporin A--a review on fermentative production, downstream processing and pharmacological applications

Biotechnol Adv. 2011 Jul-Aug;29(4):418-35. doi: 10.1016/j.biotechadv.2011.03.004. Epub 2011 Apr 5.

Authors

Shrikant A Survase¹, Lalit D Kagliwal, Uday S Annapure, Rekha S Singhal

Affiliation

¹ Food Engineering and Technology Department, Institute of Chemical Technology, Matunga, Mumbai 400019, India.

PMID: 21447377
DOI: 10.1016/j.biotechadv.2011.03.004

Abstract

In present times, the immunosuppressants have gained considerable importance in the world market. Cyclosporin A (CyA) is a cyclic undecapeptide with a variety of biological activities including immunosuppressive, anti-inflammatory, antifungal and antiparasitic properties. CyA is produced by various types of fermentation techniques using Tolypocladium inflatum. In the present review, we discuss the biosynthetic pathway, fermentative production, downstream processing and pharmacological activities of CyA.

Publication types

Review

MeSH terms

Amino Acid Sequence
Animals
Biotechnology / methods*
Cyclosporine / chemistry
Cyclosporine / metabolism*
Cyclosporine / pharmacokinetics
Cyclosporine / pharmacology*
Drug Interactions
Fermentation / drug effects*
Humans
Molecular Sequence Data
Structure-Activity Relationship

Substances

Cyclosporine