[Therapeutic angiogenesis using gene transfer and stem cell therapy in peripheral artery disease]

S Nikol

doi:10.1055/s-0031-1274561

[Therapeutic angiogenesis using gene transfer and stem cell therapy in peripheral artery disease]

Dtsch Med Wochenschr. 2011 Apr;136(14):672-4. doi: 10.1055/s-0031-1274561. Epub 2011 Mar 29.

[Article in German]

Author

S Nikol¹

Affiliation

¹ Chefärztin Klinische und Interventionelle Angiologie, Asklepios Klinik St.Georg, Lohmühlenstr. 5, 20099 Hamburg. s.nikol@asklepios.com

PMID: 21448824
DOI: 10.1055/s-0031-1274561

Abstract

The world-wide largest angiogenesis gene therapy trial in 525 patients suffering from critical limb ischemia and treated with the non-viral gene construct for fibroblast growth factor (NV1FGF) or placebo was negative for all endpoints. Also, stem cell or progenitor cell therapy did no reveal clinical benefit in patients with peripheral artery disease. Data from large randomized placebo-controlled are still not available.

Publication types

English Abstract
Review

MeSH terms

Amputation, Surgical
Angiography
Arterial Occlusive Diseases / genetics
Arterial Occlusive Diseases / mortality
Arterial Occlusive Diseases / therapy*
Controlled Clinical Trials as Topic
Fibroblast Growth Factor 1 / genetics*
Gene Transfer Techniques
Genetic Therapy / methods*
Humans
Intermittent Claudication / genetics
Intermittent Claudication / mortality
Intermittent Claudication / therapy
Ischemia / genetics
Ischemia / mortality
Ischemia / therapy
Leg / blood supply
Neovascularization, Physiologic / genetics*
Pilot Projects
Randomized Controlled Trials as Topic
Stem Cell Transplantation / methods*
Stem Cells / cytology
Treatment Failure

Substances

Fibroblast Growth Factor 1