Covered skin transcutaneous bilirubin estimation is comparable with serum bilirubin during and after phototherapy

J Perinatol. 2012 Feb;32(2):129-31. doi: 10.1038/jp.2011.66. Epub 2011 Aug 4.

Abstract

Objective: To determine whether transcutaneous bilirubin (TcB) from covered skin (TcB-C) during and after discontinuing phototherapy (PHT) is reliable in treating neonatal jaundice.

Study design: In this prospective observational study, before starting PHT, part of the forehead was covered. TcB-C and TcB from exposed skin (TcB-E) to PHT were measured before starting PHT, on a 12-hourly basis while receiving PHT and 6 h after stopping PHT. We used ANOVA (analysis of variance) and Bonferroni's t-tests.

Result: A total of 39 infants were enrolled (mean gestation 39 weeks, 51% males and 80% Hispanic). The mean TSB over all time periods was 10.9±2.4, TcB-C 10.9±2.4 and TcB-E 7.2±3.4. Before PHT, there were no significant differences in bilirubin by all three techniques. TcB-C was not significantly different from TSB at any time point. However, TcB-E was significantly lower during PHT and after stopping PHT.

Conclusion: TcB-C is a reliable method in the management of neonatal jaundice.

Publication types

  • Comparative Study

MeSH terms

  • Bilirubin / analysis*
  • Bilirubin / blood
  • Biomarkers / analysis
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Intensive Care Units, Neonatal
  • Jaundice, Neonatal / diagnosis*
  • Jaundice, Neonatal / therapy*
  • Male
  • Monitoring, Physiologic / methods
  • Phototherapy / methods*
  • Prospective Studies
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Skin / chemistry*
  • Treatment Outcome

Substances

  • Biomarkers
  • Bilirubin