Initial recovery and rebound of type f intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin

Ryan P Fagan; Karen P Neil; Randy Sasich; Carolina Luquez; Hakam Asaad; Susan Maslanka; Wajahat Khalil

doi:10.1093/cid/cir550

Initial recovery and rebound of type f intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin

Clin Infect Dis. 2011 Nov;53(9):e125-8. doi: 10.1093/cid/cir550. Epub 2011 Sep 6.

Authors

Ryan P Fagan¹, Karen P Neil, Randy Sasich, Carolina Luquez, Hakam Asaad, Susan Maslanka, Wajahat Khalil

Affiliation

¹ Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA. fev3@cdc.gov

PMID: 21896700
DOI: 10.1093/cid/cir550

Abstract

Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.

Publication types

Case Reports

MeSH terms

Aged
Botulinum Antitoxin / administration & dosage*
Botulism / drug therapy*
Botulism / pathology*
Female
Humans
Immunoglobulin Fab Fragments / administration & dosage
Immunoglobulin G / administration & dosage
Metabolic Clearance Rate
Recurrence
Time Factors
Treatment Outcome
United States

Substances

Botulinum Antitoxin
Immunoglobulin Fab Fragments
Immunoglobulin G