Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study

Fertil Steril. 2011 Dec;96(6):1370-1374.e1. doi: 10.1016/j.fertnstert.2011.09.044. Epub 2011 Nov 1.

Abstract

Objective: To investigate the value of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer (ET).

Design: Prospective randomized study.

Setting: The Egyptian IVF-ET Center.

Patient(s): Infertility patients younger than 40 years undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).

Intervention(s): The study group (n = 167) received either 100 IU of hCG (n = 83), or 200 IU of hCG (n = 84) via intrauterine administration before ET. The control group (n = 93) underwent ET without hCG. After the interim analysis, the modified study group (n = 107) received intrauterine injection of 500 IU of hCG, and the control group (n = 105) underwent ET without hCG.

Main outcome measure(s): Clinical pregnancy rate (PR) and implantation rate (IR).

Result(s): The IR and PR were statistically significantly higher in the 500 hCG group (41.6% and 75%, respectively) as compared with the control group (29.5% and 60%, respectively). The IR and PR were 26.6% and 54% in the 100 hCG group, 28.3% and 57% in the 200 IU hCG group, and 29.4% and 60% in the control group, respectively, with no statistically significant difference.

Conclusion(s): Intrauterine injection of 500 IU of hCG before ET statistically significantly improved the implantation and pregnancy rates in IVF/ICSI. CLINICAL TRIALS.GOV NUMBER: NCT 01030393.

Trial registration: ClinicalTrials.gov NCT01030393.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Chorionic Gonadotropin / administration & dosage*
  • Chorionic Gonadotropin / pharmacology*
  • Drug Administration Schedule
  • Embryo Implantation / drug effects*
  • Embryo Transfer / methods*
  • Female
  • Fertilization in Vitro* / methods
  • Humans
  • Injections
  • Pregnancy
  • Pregnancy Rate*
  • Sperm Injections, Intracytoplasmic
  • Time Factors
  • Up-Regulation
  • Uterus
  • Young Adult

Substances

  • Chorionic Gonadotropin

Associated data

  • ClinicalTrials.gov/NCT01030393