Abstract
An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-glucoside (3) were found in the plant for the first time. Compounds 2 and 3 are novel compounds. Their antiproliferation activities were tested by the MTT assay in four cell lines (breast cancer MCF-7, gastric cancer 7901, melanoma A375 and oophoroma SKOV-3).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
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Plant Roots / chemistry*
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Rumex / chemistry*
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Transition Temperature
Substances
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6-methyl-7-acetyl-1,8-dihydroxy naphthalene-1-O-beta-D(L)-glucoside
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6-methyl-7-acetyl-1,8-dihydroxy-3-methoxy naphthalene-1-O-beta-D(L)-glucoside
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Anthraquinones
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Antineoplastic Agents, Phytogenic
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Glucosides
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Naphthalenes
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chrysophanic acid