Etiology of OHSS and use of dopamine agonists

Fertil Steril. 2012 Mar;97(3):517-22. doi: 10.1016/j.fertnstert.2011.12.046. Epub 2012 Jan 21.

Abstract

Vascular endothelial growth factor is the factor that causes increased capillary permeability and therefore the most serious manifestations of ovarian hyperstimulation syndrome. Dopamine agonists can both prevent and treat ovarian hyperstimulation syndrome by blocking expression of the vascular endothelial growth factor receptor.

MeSH terms

  • Animals
  • Dopamine Agonists / therapeutic use*
  • Evidence-Based Medicine
  • Female
  • Fertility Agents, Female / adverse effects*
  • Humans
  • Ovarian Hyperstimulation Syndrome / chemically induced
  • Ovarian Hyperstimulation Syndrome / drug therapy*
  • Ovarian Hyperstimulation Syndrome / metabolism
  • Ovarian Hyperstimulation Syndrome / prevention & control*
  • Ovary / drug effects*
  • Ovary / metabolism
  • Ovulation / drug effects*
  • Ovulation Induction / adverse effects*
  • Practice Guidelines as Topic
  • Receptors, Vascular Endothelial Growth Factor / drug effects
  • Receptors, Vascular Endothelial Growth Factor / metabolism
  • Risk Assessment
  • Risk Factors
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Dopamine Agonists
  • Fertility Agents, Female
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Receptors, Vascular Endothelial Growth Factor