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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
EMBO J. 2012 Mar 7;31(5):1095-108. doi: 10.1038/emboj.2012.32. Epub 2012 Feb 17.
EMBO J. 2012.
PMID: 22343943
Free PMC article.
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.
Martina JA, Chen Y, Gucek M, Puertollano R.
Martina JA, et al.
Autophagy. 2012 Jun;8(6):903-14. doi: 10.4161/auto.19653. Epub 2012 May 11.
Autophagy. 2012.
PMID: 22576015
Free PMC article.
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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.
Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM.
Roczniak-Ferguson A, et al.
Sci Signal. 2012 Jun 12;5(228):ra42. doi: 10.1126/scisignal.2002790.
Sci Signal. 2012.
PMID: 22692423
Free PMC article.
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