Nuclease activity via self-activation and anticancer activity of a mononuclear copper(II) complex: novel role of the tertiary butyl group in the ligand frame

Inorg Chem. 2012 Mar 19;51(6):3343-5. doi: 10.1021/ic2016676. Epub 2012 Feb 28.

Abstract

The copper complex [Cu((t)BuPhimp)(Cl)] (1) derived from tridentate ligand (t)BuPhimpH having N(2)O donors was synthesized, and its molecular structure was determined. A phenoxyl radical complex was generated in solution at room temperature using Ce(IV). The nuclease and anticancer activities of 1 were investigated. The roles of the tert-butyl group and singlet oxygen in the DNA cleavage activity were also discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Copper / pharmacology*
  • Endonucleases / metabolism*
  • Humans
  • Inhibitory Concentration 50
  • Ligands

Substances

  • Antineoplastic Agents
  • Ligands
  • Copper
  • Endonucleases