Self-assembly and paclitaxel loading capacity of cellulose-graft-poly(lactide) nanomicelles

J Agric Food Chem. 2012 Apr 18;60(15):3900-8. doi: 10.1021/jf3001873. Epub 2012 Apr 4.

Abstract

A series of amiphiphilic cellulose-based graft copolymers (MCC-g-PLA) with various molecular factors were synthesized in ionic liquid BmimCl and characterized by FT-IR, (1)H NMR, (13)C NMR, XRD, and TGA. Their solubility in a variety of solvents was compared. The prepared MCC-g-PLA copolymers can self-assemble into spherical nanomicelles (10-50 nm) in aqueous solution. The self-assembly behaviors of the MCC-g-PLA copolymers were systematically investigated by fluorescence probe. Furthermore, the hydrophobic antitumor drug paclitaxel (PTX) was successfully encapsulated into the MCC-g-PLA micelles. The drug encapsulation efficiency and loading content were found to be as high as 89.30% (w/w) and 4.97%, respectively. Results in this study not only suggest a promising cellulose-based antitumor drug carrier but also provide information for property-directed synthesis of the cellulose graft PLA copolymers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Cellulose / chemistry*
  • Drug Carriers / chemistry*
  • Magnetic Resonance Spectroscopy
  • Paclitaxel / chemistry*
  • Particle Size
  • Polymers / chemistry*
  • Solubility
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Polymers
  • Cellulose
  • Paclitaxel