From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity

Jorge Iván Castillo-Quan

doi:10.1242/dmm.009894

From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity

Dis Model Mech. 2012 May;5(3):293-5. doi: 10.1242/dmm.009894.

Author

Jorge Iván Castillo-Quan¹

Affiliation

¹ Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK. ji.castillo-quan.09@ucl.ac.uk

Abstract

Summary and comment on a recent Nature paper entitled ‘A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis’ (Boström et al., 2012).

MeSH terms

Adipose Tissue, Brown / metabolism*
Adipose Tissue, White / metabolism*
Animals
Diabetes Mellitus / metabolism*
Diabetes Mellitus / pathology
Fibronectins / metabolism*
Mice
Models, Biological
Obesity / metabolism*
Obesity / pathology
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Physical Conditioning, Animal
Trans-Activators / metabolism*
Transcription Factors

Substances

FNDC5 protein, mouse
Fibronectins
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Ppargc1a protein, mouse
Trans-Activators
Transcription Factors