Abstract
A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Capsaicin / pharmacology*
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Fatty Acids, Unsaturated / pharmacology*
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Hot Temperature
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Injections, Spinal
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Movement / drug effects
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Nociceptors / drug effects
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Pain / physiopathology*
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Rats
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Spinal Cord / metabolism*
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Substance P / administration & dosage
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Substance P / metabolism*
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Synaptic Transmission / drug effects
Substances
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Fatty Acids, Unsaturated
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Substance P
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Capsaicin