Complete genome sequence of Ikoma lyssavirus

J Virol. 2012 Sep;86(18):10242-3. doi: 10.1128/JVI.01628-12.

Abstract

Lyssaviruses (family Rhabdoviridae) constitute one of the most important groups of viral zoonoses globally. All lyssaviruses cause the disease rabies, an acute progressive encephalitis for which, once symptoms occur, there is no effective cure. Currently available vaccines are highly protective against the predominantly circulating lyssavirus species. Using next-generation sequencing technologies, we have obtained the whole-genome sequence for a novel lyssavirus, Ikoma lyssavirus (IKOV), isolated from an African civet in Tanzania displaying clinical signs of rabies. Genetically, this virus is the most divergent within the genus Lyssavirus. Characterization of the genome will help to improve our understanding of lyssavirus diversity and enable investigation into vaccine-induced immunity and protection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Genome, Viral
  • Lyssavirus / classification
  • Lyssavirus / genetics*
  • Lyssavirus / isolation & purification
  • Lyssavirus / pathogenicity
  • Molecular Sequence Data
  • RNA, Viral / genetics
  • Rhabdoviridae Infections / veterinary
  • Rhabdoviridae Infections / virology
  • Tanzania
  • Viverridae / virology
  • Zoonoses / virology

Substances

  • RNA, Viral

Associated data

  • GENBANK/JX193798