Pathogenic pore-forming proteins: function and host response

Mirko Bischofberger; Ioan Iacovache; F Gisou van der Goot

doi:10.1016/j.chom.2012.08.005

Pathogenic pore-forming proteins: function and host response

Cell Host Microbe. 2012 Sep 13;12(3):266-75. doi: 10.1016/j.chom.2012.08.005.

Authors

Mirko Bischofberger¹, Ioan Iacovache, F Gisou van der Goot

Affiliation

¹ Ecole Polytechnique Fédérale de Lausanne, Global Health Institute, Station 15, CH-1015 Lausanne, Switzerland.

PMID: 22980324
DOI: 10.1016/j.chom.2012.08.005

Abstract

Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacteria / metabolism
Cell Membrane Permeability
Host-Pathogen Interactions*
Humans
Ions / metabolism
Pore Forming Cytotoxic Proteins / toxicity*

Substances

Ions
Pore Forming Cytotoxic Proteins