Single nucleotide polymorphisms of the bovine VEGF-B gene and their associations with growth traits in the Nanyang cattle breed

Y H Pang; C Z Lei; C L Zhang; X Y Lan; S M Shao; X M Gao; H Chen

doi:10.1080/10495398.2012.700290

Single nucleotide polymorphisms of the bovine VEGF-B gene and their associations with growth traits in the Nanyang cattle breed

Anim Biotechnol. 2012;23(4):225-32. doi: 10.1080/10495398.2012.700290.

Authors

Y H Pang¹, C Z Lei, C L Zhang, X Y Lan, S M Shao, X M Gao, H Chen

Affiliation

¹ College of Animal Science and Technology, Northwest A&F University, ShaanxiKey Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi, China.

PMID: 23134302
DOI: 10.1080/10495398.2012.700290

Abstract

PCR-SSCP and DNA sequencing methods were applied to reveal single nucleotide polymorphisms (SNPs) in the bovine VEGF-B gene in 675 samples belonging to three native Chinese cattle breeds. We found 3 SNPs and a duplication NC_007330.5: g. [782 A>G p. (Gly112 =) (;) 1000-1001dup CT (;) 1079 C>T (;) 2129 G>A p. (Arg184Gln)]. We also observed a statistically significant association of the polymorphism (1000-1001dup CT) in intron 3 of the VEGF-B gene with the body weight of the Nanyang cattle (p < 0.05). This polymorphisms of VEGF-B gene need to be verified among a larger cattle population before it can be identified as a marker for bovine body weight.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animal Husbandry
Animals
Body Weight / genetics
Cattle / genetics*
Cattle / growth & development*
China
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Polymorphism, Single-Stranded Conformational
Vascular Endothelial Growth Factor B / genetics*

Substances

Vascular Endothelial Growth Factor B