Abstract
Metal complexes with N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry and are now increasingly considered for the development of new chemical tools and metal based drugs. Ruthenium complexes of the type (p-cymene)(NHC)RuCl(2) interacted with biologically relevant thiols and selenols, which resulted in the inhibition of enzymes such as thioredoxin reductase or cathepsin B. Pronounced antiproliferative effects could be obtained provided that an appropriate cellular uptake was achieved. Inhibition of tumor cell growth was accompanied by a perturbation of metabolic parameters such as cellular respiration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cathepsin B / antagonists & inhibitors
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Cathepsin B / metabolism
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Cell Proliferation / drug effects
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry*
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Coordination Complexes / toxicity
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DNA / metabolism
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Embryo, Nonmammalian / drug effects
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Glutathione Reductase / antagonists & inhibitors
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Glutathione Reductase / metabolism
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HT29 Cells
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Humans
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MCF-7 Cells
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Methane / analogs & derivatives*
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Methane / chemistry
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Ruthenium / chemistry*
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Selenium Compounds / chemistry*
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Sulfhydryl Compounds / chemistry*
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Thioredoxin-Disulfide Reductase / antagonists & inhibitors
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Thioredoxin-Disulfide Reductase / metabolism
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Trypsin / chemistry
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Trypsin / metabolism
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Zebrafish / growth & development
Substances
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Coordination Complexes
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Selenium Compounds
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Sulfhydryl Compounds
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selenol
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carbene
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Ruthenium
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DNA
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Glutathione Reductase
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Thioredoxin-Disulfide Reductase
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Trypsin
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Cathepsin B
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Methane