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J Virol. 2013 Feb;87(3):1893-8. doi: 10.1128/JVI.02061-12. Epub 2012 Nov 21.

Amino acid exchanges in the putative nuclear export signal of adenovirus type 5 L4-100K severely reduce viral progeny due to effects on hexon biogenesis.

Author information

1
Heinrich Pette Institute for Experimental Virology, Hamburg, Germany.

Abstract

The adenovirus type 5 nonstructural L4-100K protein is indispensable for efficient lytic infection. During the late phase, L4-100K promotes selective translation of viral late transcripts and mediates the trimerization of the major capsid protein hexon. In the present study, the role of a potential nuclear export signal in L4-100K was investigated. Intriguingly, amino acid substitutions in this sequence resulted in severely diminished progeny virus production, seemingly by precluding proper hexon biogenesis.

PMID:
23175361
PMCID:
PMC3554178
DOI:
10.1128/JVI.02061-12
[Indexed for MEDLINE]
Free PMC Article

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