Abstract
Thiostrepton, a powerful antibiotic belonging to the thiopeptide class, was synthesized in the laboratory for the first time in 2004 through an arduous campaign involving novel strategies and tactics, scenic detours, and unexpected roadblocks. In this Review the author narrates the long journey to success, not so dissimilar to Odysseus' return voyage to Ithaca, full of adventure, knowledge, and wisdom.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis
-
Anti-Bacterial Agents / chemistry*
-
Aza Compounds / chemical synthesis
-
Aza Compounds / chemistry
-
Crystallography, X-Ray
-
Molecular Conformation
-
Penicillins / chemical synthesis
-
Penicillins / chemistry
-
Quinolines / chemistry
-
Thiostrepton / chemical synthesis
-
Thiostrepton / chemistry*
Substances
-
Anti-Bacterial Agents
-
Aza Compounds
-
Penicillins
-
Quinolines
-
Thiostrepton
-
quinaldic acid