Abstract
We performed a study on the antinociceptive effects of A1 and A2 type (A1LL and A2NTX, respectively) botulinum toxin on carrageenan-induced hyperalgesia in the rat. Both A1LL and A2NTX had antinociceptive effects in the carrageenan-induced inflammatory pain model, reducing the mechanical and thermal hyperalgesia. A2NTX also reduced the increase in c-fos immunoreactivity in L4-L5 spinal segments induced by carrageenan, suggesting that A2NTX inhibits the activation of spinal nociceptive afferent fibers that project to the CNS. Our results indicate that A2NTX may offer a new therapeutic tool to treat inflammatory pain.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Afferent Pathways / drug effects
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Afferent Pathways / physiopathology
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Analgesics / pharmacology*
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Animals
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Botulinum Toxins, Type A / pharmacology*
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Carrageenan
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Disease Models, Animal
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Edema / chemically induced
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Edema / drug therapy
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Edema / pathology
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Hot Temperature
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Hyperalgesia / chemically induced
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Hyperalgesia / drug therapy*
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Hyperalgesia / physiopathology
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Injections, Subcutaneous
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Male
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Neuromuscular Agents / pharmacology*
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Pain / chemically induced
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Pain / drug therapy*
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Pain / physiopathology
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Pain Measurement
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Physical Stimulation
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Proto-Oncogene Proteins c-fos / metabolism
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Rats
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Rats, Wistar
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Spinal Cord / drug effects
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Spinal Cord / metabolism
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Spinal Cord / pathology
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Spinal Nerves / drug effects
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Spinal Nerves / physiopathology
Substances
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Analgesics
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Neuromuscular Agents
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Proto-Oncogene Proteins c-fos
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Carrageenan
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Botulinum Toxins, Type A