Abstract
Since rhesus monkeys of Chinese origin have gained greater utilization in recent years, it is urgent to investigate the major histocompatibility complex (MHC) immunogenetics of Chinese rhesus macaques. In this study, we identified 81 Mamu-B sequences using complementary DNA cloning and sequencing on a cohort of 58 rhesus monkeys derived from three local populations of China. Twenty of these Mamu-B alleles are novel and four of them represent new lineages. Although more alleles are shared among different populations than Mamu-A locus, the Mamu-B allelic repertoires found in these three populations of Chinese macaques are largely independent, which underscores the MHC polymorphism among different populations of Chinese rhesus macaques. Our results are an important addition to the limited MHC immunogenetic information available for rhesus macaques of Chinese origin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles*
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Alternative Splicing
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Amino Acid Sequence
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Animals
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China
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Female
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Histocompatibility Antigens Class I / chemistry
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Histocompatibility Antigens Class I / genetics*
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Histocompatibility Antigens Class I / metabolism
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Macaca mulatta / classification*
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Macaca mulatta / genetics*
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Male
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Molecular Sequence Data
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Phylogeny
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Protein Sorting Signals / genetics
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Sequence Alignment
Substances
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Histocompatibility Antigens Class I
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Protein Sorting Signals
Associated data
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GENBANK/AB477391
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