Abstract
A patient with severe capillary leakage syndrome caused by a Puumala hantavirus infection was treated with a single dose of icatibant, a bradykinin receptor antagonist, with a dramatic positive response. We suggest that this drug should be tested in a larger number of patients with severe hantavirus infection.
MeSH terms
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Adult
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Bradykinin / analogs & derivatives*
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Bradykinin / therapeutic use
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Bradykinin Receptor Antagonists
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Capillary Leak Syndrome / drug therapy
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Capillary Leak Syndrome / virology
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Hantavirus Infections / drug therapy*
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Humans
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Male
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Bradykinin Receptor Antagonists
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icatibant
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Bradykinin