Abstract
N-Chlorosuccinimide is described as a widely applicable on-resin disulfide-forming reagent. Disulfide bond formation was completed within 15 min in DMF. This strategy was successfully used in the synthesis of oxytocin and a regioselective synthesis of an α-conotoxin. Moreover, disulfide formation with N-chlorosuccinimide was found to be compatible with oxidation-prone methionine and tryptophan.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Conotoxins / chemical synthesis
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Disulfides / chemistry*
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Indicators and Reagents
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Methionine / chemistry
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Molecular Structure
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Oxidation-Reduction
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Polymers / chemistry
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Solid-Phase Synthesis Techniques
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Succinimides / chemistry*
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Tryptophan / chemistry
Substances
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Conotoxins
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Disulfides
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Indicators and Reagents
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Polymers
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Succinimides
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N-chlorosuccinimide
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Tryptophan
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Methionine