Abstract
In this work, Hemigraphis alternata extract incorporated chitosan scaffold was synthesized and characterized for wound healing. The antibacterial activity of Hemigraphis incorporated chitosan scaffold (HIC) against Escherichia coli and Staphylococcus aureus was evaluated which showed a reduction in total colony forming units by 45-folds toward E. coli and 25-fold against S. aureus respectively. Cell viability studies using Human Dermal Fibroblast cells (HDF) showed 90% viability even at 48 h when compared to the chitosan control. The herbal scaffold made from chitosan was highly haemostatic and antibacterial. The obtained results were in support that the herbal scaffold can be effectively applied for infectious wounds.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acanthaceae / chemistry*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Biocompatible Materials / chemistry
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Biocompatible Materials / metabolism
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Biocompatible Materials / pharmacology
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Blood Coagulation / drug effects
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Chitosan / chemistry*
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Chitosan / metabolism
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Chitosan / pharmacology*
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Escherichia coli / drug effects
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Humans
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Hydrogels / chemistry*
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Plant Extracts / chemistry*
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Platelet Activation / drug effects
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Porosity
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Staphylococcus aureus / drug effects
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Water / chemistry
Substances
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Anti-Bacterial Agents
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Biocompatible Materials
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Hydrogels
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Plant Extracts
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Water
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Chitosan