Abstract
A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. The amino acid sequence of NDM-8 has substitutions at positions 130 (Asp to Gly) and 154 (Met to Leu) compared with NDM-1. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Bacterial Typing Techniques
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Base Sequence
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Drug Resistance, Multiple, Bacterial / drug effects*
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Drug Resistance, Multiple, Bacterial / genetics
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Escherichia coli / enzymology
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Escherichia coli / genetics*
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Escherichia coli / isolation & purification
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Escherichia coli Infections / drug therapy
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Escherichia coli Infections / microbiology
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Nepal
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RNA, Ribosomal, 16S / genetics
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
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beta-Lactams / metabolism
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beta-Lactams / pharmacology*
Substances
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Anti-Bacterial Agents
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RNA, Ribosomal, 16S
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beta-Lactams
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beta-Lactamases