The long and short of microRNA

Cell. 2013 Apr 25;153(3):516-9. doi: 10.1016/j.cell.2013.04.003.

Abstract

MicroRNAs (miRNAs) are versatile regulators of gene expression in higher eukaryotes. In order to silence many different mRNAs in a precise manner, miRNA stability and efficacy is controlled by highly developed regulatory pathways and fine-tuning mechanisms both affecting miRNA processing and altering mature miRNA target specificity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Humans
  • MicroRNAs / chemistry
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • RNA Processing, Post-Transcriptional
  • Ribonuclease III / metabolism

Substances

  • MicroRNAs
  • Ribonuclease III