Endoglin: a critical mediator of cardiovascular health

Vasc Health Risk Manag. 2013:9:195-206. doi: 10.2147/VHRM.S29144. Epub 2013 May 6.

Abstract

Endoglin (CD105) is a type III auxiliary receptor for the transforming growth factor beta (TGFβ) superfamily. Several lines of evidence suggest that endoglin plays a critical role in maintaining cardiovascular homeostasis. Seemingly disparate disease conditions, including hereditary hemorrhagic telangiectasia, pre-eclampsia, and cardiac fibrosis, have now been associated with endoglin. Given the central role of the TGFβ superfamily in multiple disease conditions, this review provides a detailed update on endoglin as an evolving therapeutic target in the management of cardiovascular disease.

Keywords: cardiac remodeling; endoglin; transforming growth factor beta; vascular.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • Cardiovascular Diseases / metabolism*
  • Cardiovascular Diseases / pathology
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular Diseases / therapy
  • Cardiovascular System / metabolism*
  • Cardiovascular System / pathology
  • Cardiovascular System / physiopathology
  • Endoglin
  • Female
  • Homeostasis
  • Humans
  • Ligands
  • Male
  • Pre-Eclampsia / metabolism
  • Pregnancy
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction
  • Telangiectasia, Hereditary Hemorrhagic / metabolism
  • Transforming Growth Factor beta / metabolism*
  • Ventricular Remodeling

Substances

  • Antigens, CD
  • ENG protein, human
  • Endoglin
  • Ligands
  • Receptors, Cell Surface
  • Transforming Growth Factor beta