Abstract
Endoglin (CD105) is a type III auxiliary receptor for the transforming growth factor beta (TGFβ) superfamily. Several lines of evidence suggest that endoglin plays a critical role in maintaining cardiovascular homeostasis. Seemingly disparate disease conditions, including hereditary hemorrhagic telangiectasia, pre-eclampsia, and cardiac fibrosis, have now been associated with endoglin. Given the central role of the TGFβ superfamily in multiple disease conditions, this review provides a detailed update on endoglin as an evolving therapeutic target in the management of cardiovascular disease.
Keywords:
cardiac remodeling; endoglin; transforming growth factor beta; vascular.
MeSH terms
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Animals
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Antigens, CD / metabolism*
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Cardiovascular Diseases / metabolism*
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Cardiovascular Diseases / pathology
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Cardiovascular Diseases / physiopathology
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Cardiovascular Diseases / therapy
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Cardiovascular System / metabolism*
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Cardiovascular System / pathology
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Cardiovascular System / physiopathology
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Endoglin
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Female
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Homeostasis
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Humans
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Ligands
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Male
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Pre-Eclampsia / metabolism
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Pregnancy
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Receptors, Cell Surface / metabolism*
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Signal Transduction
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Telangiectasia, Hereditary Hemorrhagic / metabolism
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Transforming Growth Factor beta / metabolism*
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Ventricular Remodeling
Substances
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Antigens, CD
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ENG protein, human
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Endoglin
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Ligands
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Receptors, Cell Surface
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Transforming Growth Factor beta