The first NDM metallo-β-lactamase-producing Enterobacteriaceae isolate in Poland: evolution of IncFII-type plasmids carrying the bla(NDM-1) gene

J Fiett; A Baraniak; R Izdebski; I Sitkiewicz; D Żabicka; A Meler; K Filczak; W Hryniewicz; M Gniadkowski

doi:10.1128/AAC.01197-13

The first NDM metallo-β-lactamase-producing Enterobacteriaceae isolate in Poland: evolution of IncFII-type plasmids carrying the bla(NDM-1) gene

Antimicrob Agents Chemother. 2014;58(2):1203-7. doi: 10.1128/AAC.01197-13. Epub 2013 Nov 18.

Authors

J Fiett¹, A Baraniak, R Izdebski, I Sitkiewicz, D Żabicka, A Meler, K Filczak, W Hryniewicz, M Gniadkowski

Affiliation

¹ National Medicines Institute, Warsaw, Poland.

Abstract

Poland's first Enterobacteriaceae isolate producing the New Delhi metallo-β-lactamase (NDM) was identified in August 2011. Escherichia coli sequence type ST410 NDM-1 was cultured from a critically ill patient who had been transferred directly from the Congo. The blaNDM-1 gene was carried by conjugative IncFII-type plasmid pMC-NDM (87,619 bp), which showed structural similarity to plasmid pGUE-NDM, which was identified earlier in France in an E. coli ST131 isolate of Indian origin.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / therapeutic use
Drug Resistance, Multiple, Bacterial
Escherichia coli / genetics*
Escherichia coli / isolation & purification
Escherichia coli Infections / drug therapy
Escherichia coli Infections / microbiology*
Escherichia coli Infections / pathology
Fatal Outcome
Gene Expression
Humans
Male
Middle Aged
Multilocus Sequence Typing
Plasmids / chemistry*
Poland
beta-Lactamases / genetics*

Substances

Anti-Bacterial Agents
beta-Lactamases
beta-lactamase NDM-1