Astrocytes and the evolution of the human brain

Med Hypotheses. 2014 Feb;82(2):236-9. doi: 10.1016/j.mehy.2013.12.004. Epub 2013 Dec 15.

Abstract

Cells within the astroglial lineage are proposed as the origin of human brain evolution. It is now widely accepted that they direct mammalian fetal neurogenesis, gliogenesis, laminar cytoarchitectonics, synaptic connectivity and neuronal network formation. Furthermore, genetic, anatomical and functional studies have recently identified multiple astrocyte exaptations that strongly suggest a direct relation to the increased size and complexity of the human brain.

MeSH terms

  • Animals
  • Apoptosis
  • Astrocytes / cytology*
  • Biological Evolution
  • Brain / pathology*
  • Brain / physiology*
  • Cell Differentiation
  • Cell Lineage
  • Cognition
  • Genetic Variation
  • Haplorhini
  • Humans
  • Mice
  • Models, Theoretical
  • Neurogenesis
  • Neuroglia / metabolism
  • Neurons / metabolism
  • Neurons / pathology
  • Signal Transduction
  • Stem Cells / cytology
  • Thrombospondins / metabolism

Substances

  • Thrombospondins