Full-genome analysis of a canine pneumovirus causing acute respiratory disease in dogs, Italy

PLoS One. 2014 Jan 6;9(1):e85220. doi: 10.1371/journal.pone.0085220. eCollection 2014.

Abstract

An outbreak of canine infectious respiratory disease (CIRD) associated to canine pneumovirus (CnPnV) infection is reported. The outbreak occurred in a shelter of the Apulia region and involved 37 out of 350 dogs that displayed cough and/or nasal discharge with no evidence of fever. The full-genomic characterisation showed that the causative agent (strain Bari/100-12) was closely related to CnPnVs that have been recently isolated in the USA, as well as to murine pneumovirus, which is responsible for respiratory disease in mice. The present study represents a useful contribution to the knowledge of the pathogenic potential of CnPnV and its association with CIRD in dogs. Further studies will elucidate the pathogenicity and epidemiology of this novel pneumovirus, thus addressing the eventual need for specific vaccines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Disease Outbreaks
  • Dog Diseases / epidemiology*
  • Dog Diseases / virology*
  • Dogs
  • Female
  • Gene Order
  • Genome, Viral*
  • Italy / epidemiology
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • Pneumovirus / classification
  • Pneumovirus / genetics*
  • Pneumovirus / isolation & purification
  • Pneumovirus Infections / veterinary*
  • Sequence Alignment

Associated data

  • GENBANK/KF015281

Grants and funding

This work was supported by grants from the Italian Ministry of Health, Ricerca corrente 2009, project IZS VE 21/09 RC “Definizione di una procedura validata per la selezione di cani per programmi di Interventi Assistiti dagli Animali (IAA)”. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.