Commentary on ''dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation''

Torsten Zuberbier; Margitta Worm

doi:10.1038/jid.2013.436

Commentary on ''dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation''

J Invest Dermatol. 2014 Feb;134(2):302-303. doi: 10.1038/jid.2013.436.

Authors

Torsten Zuberbier¹, Margitta Worm²

Affiliations

¹ Department of Dermatology and Allergy, Allergy-Centre-Charité, Charité-University Hospital Berlin, Berlin, Germany. Electronic address: torsten.zuberbier@charite.de.
² Department of Dermatology and Allergy, Allergy-Centre-Charité, Charité-University Hospital Berlin, Berlin, Germany.

PMID: 24424451
DOI: 10.1038/jid.2013.436

Abstract

Matsui et al. (2014) delineate a novel pathomechanism for attenuated sweating in atopic dermatitis (AD). They provide evidence that acetylcholine-induced sweating can be inhibited via H1-receptor activation. This work suggests that H1 blockers may be useful in patients with AD.

Publication types

Comment

MeSH terms

Acetylcholine / metabolism*
Animals
Dermatitis, Atopic / metabolism*
Female
Glycogen Synthase Kinase 3 / metabolism*
Glycogen Synthase Kinase 3 beta
Humans
Hypohidrosis / metabolism*
Receptors, Histamine H1 / genetics*
Sweating / physiology*

Substances

Receptors, Histamine H1
GSK3B protein, human
Glycogen Synthase Kinase 3 beta
Glycogen Synthase Kinase 3
Acetylcholine