Toll-like receptor genetic variants and colorectal cancer

Oncoimmunology. 2014 Jan 1;3(1):e27763. doi: 10.4161/onci.27763. Epub 2014 Jan 10.

Abstract

Single-nucleotide polymorphisms in Toll-like receptor 5 (TLR5), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a link between TLRs and CRC that may have both therapeutic and prognostic/predictive implications.

Keywords: Toll-like receptors; biomarker; colorectal cancer; flagellin; single-nucleotide polymorphism.